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The effects of RPM on the transcriptome profile during follicular and early embryo were investigated, and the results showed that it is likely that DNA methylation may have been a mechanism utilized to modulate gene expression patterns (Peagaricano et al., 2013)

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However, some studies on stem cell recovery in keratinocytes showed that copper-free GHK retained meaningful activity, suggesting the peptide backbone itself carries intrinsic biological information